The modern strategies of clinical management of vitamin D deficiency in practices of the obstetrician gynecologist




vitamin D, reproductive system, PCOS, endometriosis, uterine fibroid, preeclampsia, infertility


Low vitamin D concentrations were presented in a significant proportion of the population. Many diseases in people, both middle and old, were directly associated with vitamin D deficiency. The effect of vitamin D levels on reproductive function in both men and women has been proven. Low vitamin D concentrations have been associated with a wide range of adverse maternal and offspring health outcomes in observational epidemiological studies.

Complications of pregnancy with a low level of vitamin D are pre-eclampsia, gestational diabetes and premature birth. It is proved that the appointment of vitamin D to women during pregnancy reduces the proportion of cesarean section in delivery. Numerous authors prove the role of vitamin D in the pathogenetic chain of the polycystic ovary syndrome. It was found that during the menopause due to the violation of steroidogenesis there is a loss of bone mass due to vitamin D deficiency. In addition, a decrease in the level of vitamin D is associated with the occurrence of uterine fibroids.

However, despite a dearth of interventional evidence supporting supplementation/treatment of vitamin D in randomised controlled trial settings, it is generally accepted that supplementation/treatment is not harmful and may have some significant short- and long-term health benefits. In this regard, timely correction of vitamin D deficiency becomes very important in solving reproductive problems. This review focuses on the problem of correcting the level of vitamin D in different population groups. Treatment of vitamin D deficient women and vitamin D supplementation is safe and is recommended for all women who are pregnant or breastfeeding.

Author Biographies

О. В. Булавенко, Vinnytsia National Pirogov Memorial Medical University

MD, professor, head of Obstetrics and Gynecology Department No. 2

Т. Ф. Татарчук, SI “Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”

MD, professor, corresponding member of the NAMS of Ukraine, deputy director for research work, сhief of the Endocrine Gynecology Department

Д. Г. Коньков, Vinnytsia National Pirogov Memorial Medical University

MD, associate professor at the Obstetrics and Gynecology Department No. 1

О. В. Фурман, Vinnytsia National Pirogov Memorial Medical University

PhD, associate professor at the Obstetrics and Gynecology Department No. 2


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