Prediction of development of severe forms of endometriosis in women of reproductive age

Н. Ф. Захаренко

Abstract


The article describes the algorithm for predicting the development of severe forms of endometriosis and a mathematical model for predicting the severity of this pathology, used for the identification of risk groups and the timely conduct of preventive measures. The application of this method makes it possible to predict not only the fact of the pathology occurrence, but also the degree of probability of its occurrence.

123 women of reproductive age were examined: 79 with severe forms of endometriosis and 44 healthy women. The method of step-by-step discriminant analysis has identified 8 of the 65 factors that most affected the occurrence of severe form of endometriosis: the chronic stress, especially in puberty, unfavorable ecological conditions of residence, early menarche, manifestations of dysmenorrhea, gastrointestinal tract diseases, abortions in anamnesis, surgical interventions and inflammatory diseases of the reproductive system.

Sensitivity of the prediction algorithm for severe endometriosis in the research retrospective sample was 89.87%: out of 79 women with endometriosis 71 cases of its severe form were predicted with high or moderate probability. Accuracy for a high-risk group of severe endometriosis was 94.1%, mean form – 84.8%, and overall system accuracy was 83.75%: out of 80 women with severe or moderate probability of severe endometriosis it was actually observed in 67. Out of 43 patients whose endometriosis was not predicted, in 39 it did not really exist, i. e. for the low-risk group the accuracy of the prediction was 90.69%. Of the 87 women in the control group who were diagnosed with severe endometriosis, 80 (91.95%), according to the forecast, expected its occurrence with high or moderate probability, which confirms the high sensitivity of the prognostic system.

The developed algorithm and the mathematical model of prediction of a severe form of endometriosis are highly informative and provide the opportunity to form risk groups of disease developing, taking into account the degree of its occurrence probability for the prior conduct of individualized preventive measures.


Keywords


endometriosis; prevention; prediction

References


Zakharenko, N.F., Tatarchuk, T.F., Kovalenko, N.V. “The role of oxidative stress in the genesis of endometriosis.” Reproductive endocrinology 4 (2014): 13–16.

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GOST Style Citations


1. Захаренко, Н.Ф. Роль оксидативного стресу в ґенезі ендометріозу / Н.Ф. Захаренко, Т.Ф. Татарчук, Н.В. Коваленко // Репродуктивна ендокринологія. – 2014. – №4. – С. 13–16.

2. Ким, Дж.-О., Мьюллер, Ч.У., Клекка, У.Р. и др. Факторный, дискриминантный и кластерный анализ: Пер. с англ. / Под ред. И.С. Енюкова. – М.: Финансы и статистика, 1989. – 215 с.

3. Мінер, О.П., Москаленко, В.З., Веселий, С.В. Інформаційні технології в хірургії. – К.: Вища школа, 2004. – С. 109–173.





DOI: https://doi.org/10.18370/2309-4117.2018.39.34-37

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ISSN 2411-1295 (Online), ISSN 2309-4117 (Print)