Modern methods of treatment of cervix inflammatory diseases in women of reproductive age. Literature review




cervicitis, ectopia and erosion of the cervix, etiology and pathogenesis of inflammation, benzidamine hydrochloride, Tantum Rosa, Nifuratel, Macmiror Complex


The article describes contemporary views on the problem of inflammatory diseases of the cervix uterus – cervicitis with the presence of ectopia, erosion, ectropion or without them. The emphasis is placed on the fact that the development of the disease occurs due to two reasons: the persistent action (persistence) of the pathogen – the etiology of inflammation; increased concentration of proinflammatory cytokines – tumor necrosis factor and interleukin-1 – pathogenesis of inflammation. Cytokine-induced activation and output of leukocytes from the vascular bed leads to tissue damage, the development of clinical manifestations of inflammation, promotes chronization of the process and the occurrence of relapses. Therefore, rational treatment of inflammatory diseases of the cervix must be comprehensive and include an etiotropic and pathogenetic component.

When choosing etiotropic therapy, it is necessary to take into account the increasing resistance of pathogens to major activated heric remedies. In this case, resistance to nitrofuran occurs very rarely. Nifuratel (Macmiror Complex) is a nitrofuran of the last generation, the only preparation of this group for local application in gynecology, has a pronounced bactericidal effect against a wide range of pathogens (bacteria, mushrooms, protozoa) and provides a reliable eradication of microorganisms. In the Macmiror Complex vaginal cream, the expressed bactericidal effect of nifuratel is combined with high fluidity and pronounced adhesive properties of the carbomeric basis of the cream, which provides a reliable coating of the cervix and a high concentration of the active substance in the focal point of the lesion.

Benzodiamine hydrochloride (Tantum RosaR) is the only local non-steroidal anti-inflammatory agent in gynecology, which provides powerful suppression of the synthesis of proinflammatory cytokines, the tumor necrosis factor and interleukin-1, at the very earliest stages, as the recommended pathogenetic therapy of inflammation. Thus, the combination therapy of Macmiror Complex vaginal cream (nifuratel) and Tantum RosaR (benzidamine hydrochloride) has a comprehensive effect on the etiology and pathogenesis of the disease, provides a compelling clinical recovery and prevent relapse in inflammatory diseases of the cervix.

Author Biographies

А. Е. Дубчак, SI “Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”

MD, professor, chief researcher at the Rehabilitation of Women Reproductive Function Department

А. В. Милевский, SI “Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”

MD, professor, chief researcher at the Rehabilitation of Women Reproductive Function Department


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How to Cite

Дубчак, А. Е., & Милевский, А. В. (2018). Modern methods of treatment of cervix inflammatory diseases in women of reproductive age. Literature review. REPRODUCTIVE ENDOCRINOLOGY, (39), 16–20.



Tumors and pretumoral pathology