Prediction of heavy degree of flow of menopausal disorders for women with hyperproliferative processes of reproductive system using a mathematical model
Keywords:menopausal disorders, prognostication, mathematical model, hyperproliferative processes of reproductive system
Objective. Prognostication of heavy degree of flow of menopausal disorders in women with hyperproliferative processes of reproductive system.
Materials and methods. For the exposure of factors, related to severity of flow of climacteric syndrome (CS) and estimation of degree of their influence on development of heavy degree of flow of menopausal disorders, the method of construction and analysis of multivariable mathematical models was utilized. The results of investigation of 19 indexes from 124 women aged 45 to 79 with menopausal disorders (climacteric syndrome) and with signes of hyperproliferative processes of reproductive system according to the data of ultrasound survey of uterus and the results of histology investigations of uterine mucosal scrapings were used for construction of model.
Results of the study. On the basic of analysis of coefficients of logical model of regress the result was determined. Presence in women operation on the appendages of uterus promotes the risk of development of heavy degree of flow of disorders in menopause (p = 0.006) with odds ratio (OR) = 7.6 and the 95% confidence interval (CI) 1.8–32.8. Presence of chronic inflammatory diseases of privy parts (p = 0.004, OR = 27.6, 95% CІ 2.8–269.7), presence of hypermenstrual syndrome (p = 0.009, OR = 7.0, 95% CI 1.6–29.7), presence of diseases of liver and bilious ducts (p = 0.001, OR = 9.9, 95% CI 2.5–40.1), presence of stomach and intestine diseases (p = 0.010, OR = 5.9, 95% CI 1.5– 23.0) promotes the risk of development of heavy degree of flow of menopausal disorders.
Conclusions. Presence for women with hyperproliferative processes of the reproductive system an operation on the appendages of uterus, chronic inflammatory diseases of genitals, hypermenstrual syndrome, diseases of liver and bilious ducts, stomach and intestine promotes the risk of development of heavy degree of flow of menopausal disorders.
- Akhrypkina, T.L. Clinical, hormonal and metabolic parameters in perimenopause in women with polycystic ovary syndrome in anamnesis. Thesis abstract for PhD degree, specialty 14.01.01. Kharkiv State Medical University (Kharkiv): 20 p.
- Vikhlyaeva, E.M. “Postmenopausal syndrome and the strategy of hormone replacement therapy.” Obstetrics and Gynecology 5 (1997): 51–6.
- Kosei, N.V., Tatarchuk, T.F., Solsky, Y.P. “Non-hormonal therapy of climacteric syndrome in women after hysterectomy with respect to uterine fibroids.” Art of treatment 2 (2003): 53–6.
- Lyakh, Y.E., Guryanov, V.G. “Mathematical modeling in solution of classification problems in biomedicine.” Ukrainian Journal of Telemedicine and Medical Telematics 10.2 (2012): 69–76.
- Makarchuk, O.M., Pankov, O.I. “Features of the functional state of the liver in women of the perimenopausal age.” Collection of scientific works of the Association of Obstetricians-Gynecologists of Ukraine. Kyiv. Intermed (2009): 374–8.
- Petri, A., Sabin, K. Visual statistics in medicine. Trans. from Eng. V.P. Leonov. Moscow. GEOTAR-MED (2003): 144 p.
- Plotnikova, V.N., Lutsenko, N.S., Shikaeva, F.V., et al. “The state of neuroendocrine regulation of adaptation in patients with chronic salpingooophoritis.” Collection of scientific works of the Association of Obstetricians-Gynecologists of Ukraine. Kyiv. Intermed (2006): 544–7.
- Smetnik, V.P., Tkachenko, N.M., Glaser, G.A., Moskalenko, N.P. Climacteric syndrome. Moscow. Medicine (1988): 288 p.
- Tatarchuk, T.F., Burlaka, E.V. “Modern principles of diagnosis and treatment of endometrial hyperplastic processes.” Women’s health 4.16 (2003): 107–14.
- Tatarchuk, T.F. “Hormone replacement therapy. Questions and answers.” International Endocrinology Journal 4.10 (2007): 59–65.
- Shapovalenko, S.A. “Features of gastrointestinal system dysfunction in perimenopausal women.” Russian bulletin of obstetrician-gynecologists 4 (1999): 112–5.
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