Modern approaches to correction of vaginal microbiocenosis at the stage of preconceptional preparation




preconceptional preparation, non-specific vulvovaginitis, treatment, Depantol


Today in Ukraine and in the world there is a tendency to increase the age of both primiparous women and women, which delay the birth of the second child. This creates certain risks with regard to the increase in the population of women of reproductive age the frequency of extragenital pathology and diseases of the female genital area, in particular, infectious genesis. In this regard, correction of the vaginal microbiocenosis at the stage of pre-conceptual preparation acquires special significance.

The aim of the study to evaluate the effectiveness of the drug Depantol for the treatment of nonspecific vulvovaginitis at the stage of pre-conceptual preparation.

Under supervision there were 45 women aged 24–32 years. The diagnosis of non-specific vulvovaginitis verified according to the clinical and laboratory methods of the study. All patients was prescribed the drug Depantol by 1 suppository 2 times a day for 10 days. Treatment efficacy was evalued according to the clinical and microbiological examination before treatment, and at 1 and 3 months after treatment.

As a result of the study, the clinical and laboratory efficacy of the proposed therapy was substantiated. The absence of subjective symptoms after treatment was ascertained, bacteriological study confirmed the effectiveness of therapy in 95.6% of cases.

The author of the study notes that the drug Depantol is highly effective in relation to the main pathogens of non-specific vulvovaginitis, which makes it the drug of choice in preconception preparation. Depantol does not interfere with the functional activity of lactic acid bacteria, which contributes to the rapid restoration of the normal biotope of the vagina and creates favorable conditions for conception.

Author Biography

О. В. Кравченко, Bukovinian State Medical University

Obstetrics, Gynecology and Perinatology Department


  1. Borovkova, E.I. “Interaction of pathogens with a pregnant woman as a risk factor for intrauterine infection of the fetus.” Women’s health 2 (2013): 95–8.
  2. Kira, E.F., Muslimova, S.Z. “Non-specific vaginitis and its effect on the reproductive health of a woman (literature review).” Problems of reproduction 5 (2008): 8–13.
  3. Radzinskyi, V.E., Khamoshina, M.B., Kaigorodova, L.A., et al. “Correction of violations of the biocenosis of the vagina: march in place or move forward?” Reproductive endocrinology 4.18 (2014): 92–100.
  4. Lekareva, T.M. “Pre-conceptual preparation: favorable outcome of the desired pregnancy.” TERRA MEDICA NOVA 3 (2009): 14–8.
  5. Novikova, O.N., Ushakova, G.A., Vavin, G.V. “State of health and mediators of the immune response in newborns with intrauterine infection.” Siberian Medical Journal 28.2 (2013): 59–63.
  6. Perinatal infections: a practical guide. Ed. by A.Y. Senchuk, Z.M. Dubossarskaya. Moscow. MIA (2005): 318 p.
  7. Nisevich, L.L., Adieva, A.A., Medzhidova, D.B., et al. “Preconceptual preparation of women for pregnancy and its effect on the health of the fetus and the child.” Pediatric Pharmacology 5.6 (2008): 45–51.
  8. Tebelev, B.G., Rogozhina, I.E. “The main reasons and methods of preventing early reproductive losses.” Saratov Journal of Medical Scientific Research 3 Vol. 7 (2011): 593–8.
  9. Tyutyunnik, V.P. “Prophylaxis and treatment of placental insufficiency of infectious genesis.” Russian Medical Journal 18.4 (2008): 1122–6.
  10. Fedorova, J.P., Manullina, N.K. “Role of opportunistic microflora and microbial associations in infection of the ancestral tracts.” Kazan Medical Journal 1 (2011): 112–6.
  11. Yamamoto, T., Zhou, X., Williams, C.J., et al. “Bacterial populations in the vaginas of healthy adolescent women.” J Pediatr Adolesc Gynecol 22 (2009): 11–8.
  12. Centers for Disease Control and Prevention. “Recommendations for improving preconception health and health care: United States: a report of the CC/ATSDR Preconception Care workgroup and the Select Panel on Preconception care.” Morb Mortal Weekly Rep 55 (2006): 1–23.
  13. Razzak, M.S., Al-Charrakh, A.H., Al-Greitty, B.H. “Relationship between lactobacilli and opportunistic bacterial pathogens associated with vaginitis.” N Am J Med Sci 3.4 (2011): 185–92.
  14. Ravel, J., Gajer, P., Abdo, Z., et al. “Vaginal microbiome of reproductive-age women.” Proc Natl Acad Scien USA 108.1 (2011): 4680–7.



How to Cite

Кравченко, О. В. (2017). Modern approaches to correction of vaginal microbiocenosis at the stage of preconceptional preparation. REPRODUCTIVE ENDOCRINOLOGY, (38), 26–29.



Inflammatory diseases

Most read articles by the same author(s)

1 2 > >>