Melatonin: influence on life quality and personality profile of women of late reproductive and pre-menopausal age with endometrial pathology

С. М. Корниенко, Ю. В. Давыдова

Abstract


The aim of the work. To investigate the relationship of melatonin with the quality of life and the profile of the personality of women of late reproductive and premenopausal age with the pathology of the endometrium.

Materials and methods. 45 women aged 36–55 years with endometrial diseases were examined. All patients underwent hysteroscopy. The personality profile was assessed using the FPI test. To study the quality of life, the SF-36 questionnaire was used. The data was processed using the Spearman rank correlation.

Results. As a result of the correlation analysis of data on melatonin concentration and SF-36 scales, our study found that the value of melatonin did not affect the quality of life associated with health. However, if we evaluate trends, then the highest of the reduced correlation coefficients is of some interest. It’s about role physical functioning. The correlation coefficients of the melatonin index and the scales of the FPI questionnaire looked as follows: all significant correlation coefficients had a negative sign, that is, the personality properties corresponding to these coefficients were associated with a low concentration of melatonin. The ordering of the FPI scales by decreasing the significance of the correlation coefficients helped to identify the personal profile of hypomelatoninemia in the examined women. First of all, it was characterized by high levels of depressiveness and emotional lability.

Conclusions. In the psychopathological structure of the personality of women of late reproductive and pre-menopausal age with endometrial pathology burdened with hypomelatoninemia, depressive and emotional lability is predominate. Reducing the secretion of melatonin is also associated with increased spontaneous aggressiveness, neuroticism and irritability.


Keywords


premenopausal women; endometrial pathology; melatonin

References


Asarnow, L.D., Soehner, A.M., Harvey, A.G. “Circadian rhythms and psychiatric illness.” Curr Opin Psychiatry 26.6 (2013): 566–71. DOI: 10.1097/YCO.0b013e328365a2fa

Choi, D. “Potency of melatonin in living beings.” Dev Reprod 17.3 (2013): 149–77. DOI: 10.12717/DR.2013.17.3.149

Comai, S., Gobbi, G. “CCNP Award Paper: Unveiling the role of melatonin MT2 receptors in sleep, anxiety and other neuropsychiatric diseases: a novel target in psychopharmacology.” J Psychiatry Neurosci 39.1 (2014): 6–21. DOI: 10.1503/jpn.130009

Courtet, P., Olié, E. “Circadian dimension and severity of depression.” Eur Neuropsychopharmacol 22.3 (2012): 476–81. DOI: 10.1016/j. euroneuro.2012.07.009

Harb, F., Hidalgo, M.P., Martau, B. “Lack of exposure to natural light in the workspace is associated with physiological, sleep and depressive symptoms.” Chronobiol Int 32.3 (2015): 368–75. DOI: 10.3109/07420528.2014.982757

Haridas, S., Kumar, M., Manda, K. “Melatonin ameliorates chronic mild stress induced behavioral dysfunctions in mice.” Physiol Behav 119 (2013): 201–7. DOI: 10.1016/j.physbeh.2013.06.015

Guesdon, V., Malpaux, B., Delagrange, P., et al. “Rapid effects of melatonin on hormonal and behavioral stressful responses in ewes.” Psychoneuroendocrinology 38.8 (2013): 1426–34. DOI: 10.1016/j.psyneuen.2012.12.011

Ito, Y., Iida, T., Yamamura, Y., et al. “Relationships between Salivary Melatonin Levels, Quality of Sleep, and Stress in Young Japanese Females.” Int J Tryptophan Res 6.1 (2013): 75–85. DOI: 10.4137/IJTR.S11760

Srinivasan, V., DeBerardis, D., Shillcutt, S.D., Brzezinski, A. “Role of melatonin in mood disorders and the antidepressant effects of agomelatine.” Expert Opin Investig Drugs 21.10 (2012): 1503–22. DOI: 10.1517/13543784.2012.711314

Sharkey, K.M., Pearlstein, T.B., Carskadon, M.A. “Circadian phase shifts and mood across the perinatal period in women with a history of major depressive disorder: a preliminary communication.” J Affect Disord 150.3 (2013): 1103–8. DOI: 10.1016/j.jad.2013.04.046


GOST Style Citations






DOI: https://doi.org/10.18370/2309-4117.2017.37.75-77

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

ISSN 2411-1295 (Online), ISSN 2309-4117 (Print)