Pregnancy and polymorphisms in folate-cycle genes: what dose and formulation of folates to choose?


  • Н. А. Курмачёва Saratov Regional Center for Family Health Protection and Reproduction, Russian Federation
  • Е. В. Верижникова Affiliate of the Reaviz Medical University, Saratov, Russian Federation
  • О. М. Харитонова Saratov Regional Center for Family Health Protection and Reproduction, Russian Federation



pregnancy, miscarriage, polymorphisms in the folate-cycle genes, hyperhomocysteinemia, metafolin, folic acid


Study objectives: To compare the course of pregnancy and perinatal outcomes of term delivery in women with polymorphisms in the folatecycle genes and a history of miscarriage, depending on what strategy was chosen to correct folate deficiency.

Study design: This was a retrospective, comparative study.

Materials and methods: We analyzed medical records of 114 patients (Medical Forms No. 025/у, 111/у and 113/у) with polymorphisms in the folate-cycle genes and a history of miscarriage. In Group I, 54 women received conventional treatment with folic acid (5.8 mg/day) before conception and until week 28 of pregnancy as a combination of a single supplement or a vitamin B complex with vitamin-mineral combination supplements. In Group II, 60 patients received a vitamin-mineralcombination supplement, containing 208 mg of metafolin and 200 mg of folic acid, and other B vitamins (В1, В2, В5, В6 and В12) before conception and throughout pregnancy. Also, we compared the levels of homocysteine, blood-coagulation parameters, the course of pregnancy and delivery, and the health state of newborns.

Study results: Compared to patients in Group I, patients in Group II had significantly lower levels of homocysteine, fibrinogen and the markers of abnormally increased blood levels of thrombin. In the second group, the rates of some obstetrical and perinatal complications were also lower (1.5–3.9-fold, p < 0.05) than in the first group.

Conclusion: In women with polymorphisms in the folate-cycle genes and a history of miscarriage, the use of vitamin-mineral-combination supplements, containing an active form of folates (metafolin), improves the course of pregnancy and perinatal outcomes of term delivery.

Author Biographies

Н. А. Курмачёва, Saratov Regional Center for Family Health Protection and Reproduction

MD, head of Prophylaxis of the Reproductive System Department

Е. В. Верижникова, Affiliate of the Reaviz Medical University, Saratov

MD, professor, head of Pharmacy and Pharmacology Department

О. М. Харитонова, Saratov Regional Center for Family Health Protection and Reproduction

MD, head of Reproduction Department


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How to Cite

Курмачёва, Н. А., Верижникова, Е. В., & Харитонова, О. М. (2017). Pregnancy and polymorphisms in folate-cycle genes: what dose and formulation of folates to choose?. REPRODUCTIVE ENDOCRINOLOGY, (36), 96–102.



Pregnancy and childbirth