Possibilities for therapy of a comorbidity of uterine myoma and benign breast dysplasias

В. Е. Радзинский, И. М. Ордиянц, М. Н. Масленникова, Е. А. Павлова, В. В. Карданова


Objective. To improve the reproductive health of women with benign breast dysplasia (BBD) and uterine myoma, by elaborating a differentiated approach to preventing and treating comorbid diseases.

Subject and methods. The investigation included 175 women with concomitant genital diseases and BBD who were treated at the Gynecology Unit of the City Clinical Hospital No. 12, Moscow. The results of their examination and differentiated treatment for comorbid diseases of the uterus and breast were analyzed.

Results. The altered ratio of steroid hormone levels as absolute or relative hyperestrogenemia underlies the pathogenesis of BBD in women with uterine myoma. The elaborated differentiated approach allows quality of life to be improved of 43.4% of patients with combined diseases of the mammary glands and genitals, to reduce the progression and recurrence of BBD in patients with uterine myoma from 36.7 to 15.9%.

Conclusion. The findings strongly suggest that the women of this category must form a special follow-up gynecological group and their treatment must be a preventive measure against the progression and recurrence of BBD.


benign breast dysplasia; uterine myoma


Gynecology: National leadership Ed. by V.I. Kulakov, I.B. Manukhin, G.M. Savelieva. Moscow. GEOTAR-Media (2007): 1072 p.

Suturina, L.V., Popova, L.N. “Effect of bromocriptine and cyclodinone on clinical symptoms and prolactin levels with reproductive age hyperprolactinemia.” Questions of gynecology, obstetrics and perinatology 9.2 (2010): 41–3.

Khaskhanova, L.H. Forecasting, early diagnosis and treatment of non-cancerous diseases of the mammary glands after surgical treatment of gynecological diseases. Thesis abstract for MD degree. Moscow (2003): 47 p.

Konovalova, V.N. “Discussion questions of tactics of conducting women with benign diseases of mammary glands.” Effective pharmacotherapy in obstetrics and gynecology 6 (2009): 6–12.

Prilepskaya, V.N., Tagieva, T.T. “Fibrous-cystic disease of mammary glands: the possibility of non-hormonal therapy.” Medline-Express 5 (2008): 10–7.

Filippov, O.S. Benign mammary gland diseases. Moscow. MEDPress-Inform (2008): 112 p.

Radzinsky, V.E. Medicinal plants in obstetrics and gynecology. 8th ed. Moscow. EKSMO (2008): 317 p.

Rozhkova, N.I., Meskikh, E.V. “Mastodinone: possibilities of application at various forms of mastopathy.” Tumors of the female reproductive system 4 (2008): 46–7.

Radzinsky, V.E. Mammary glands and gynecological diseases. Moscow. Status Praesens (2010): 304 p.

GOST Style Citations

1. Гинекология: Национальное руководство Под ред. В.И. Кулакова, И.Б. Манухина, Г.М. Савельевой. М.: ГЭОТАР-Медиа, 2007. –1072 с.

2. Сутурина, Л.В. Влияние бромкриптина и циклодинона на клинические симптомы и уровень пролактина с гиперпролактинемией репродуктивного возраста / Л.В. Сутурина, Л.Н. Попова // Вопросы гинекологии, акушерства и перинатологии. – 2010. – №9 (2). – С. 41–43.

3. Хасханова, Л.Х. Прогнозирование, ранняя диагностика и лечение нераковых заболеваний молочных желез после хирургического лечения гинекологических заболеваний : Автореф. дис. … д-ра мед. наук / Л.Х. Хасханова. – М., 2003. – 47 с.

4. Коновалова, В.Н. Дискуссионные вопросы тактики ведения женщин с доброкачественными заболеваниями молочных желез / В.Н. Коновалова // Эффективная фармакотерапия в акушерстве и гинекологии. – 2009. – №6. – С. 6–12.

5. Прилепская, В.Н. Фиброзно-кистозная болезнь молочных желез: возможности негормональной терапии / В.Н. Прилепская, Т.Т. Тагиева // Медлайн-Экспресс. – 2008. – №5. – С. 10–17.

6. Филиппов, О.С. Доброкачественные заболевания молочных желез. – М.: МЕДПресс-информ, 2008. – 112 с.

7. Радзинский, В.Е. Лекарственные растения в акушерстве и гинекологии. 8-е изд. – М.: ЭКСМО, 2008. – 317 с.

8. Рожкова, Н.И. Мастодинон: возможности применения при различных формах мастопатии / Н.И. Рожкова, Е.В. Меских // Опухоли женской репродуктивной системы. – 2008. – №4. – С. 46–47.

9. Радзинский, В.Е. Молочные железы и гинекологические болезни. – М.: Status Praesens, 2010. – 304 с.

DOI: https://doi.org/10.18370/2309-4117.2017.36.86-89


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

ISSN 2411-1295 (Online), ISSN 2309-4117 (Print)