Endometrium in focus of the gynecologist’s attention: the role of hysteroscopy and immunohistochemistry in the diagnosis of chronic endometritis, the choice of treatment


  • І. Т. Кишакевич Ivano-Frankivsk National Medical University, Ukraine https://orcid.org/0000-0001-8294-431X
  • Н. В. Коцабин Ivano-Frankivsk National Medical University, Ukraine
  • В. В. Радченко Dnipro Medical Academy of the MOH of Ukraine, Ukraine




chronic endometritis, infertility, hysteroscopy, CD138, Epigalin


The aim of the study was to evaluate the immunohistochemical marker CD138 for the diagnosis of chronic endometritis in women with infertility and to explore the impact and effectiveness of Epigalin® (indole-3-carbinol – 200 mg, epigallocatechin-3-gallate – 45 mg) on the state of the endometrium based on established key relationships between structural and functional state of the endometrium, morphological and imunoglobulin features.

Materials and methods: the study included 46 women of reproductive age with infertility, ranging in age from 20 to 45 years. All women were carried out hysteroscopy with endometrial biopsy with subsequent morphological study of the endometrium and determination CD138 expression (membrane protein used as a marker of plasma cells).

Patients were randomized into two equal groups. The first group received traditional antibiotic therapy, women of the second group in combination with antibacterial therapy received Epigalin® 1 capsule twice a day for 3 months.

Monitoring the effectiveness of therapeutic interventions was carried out through 3 months after treatment conducted. Repeated CD138 expression was determined in endometrial samples obtained during Pipelle biopsy of the endometrium, which was carried out on 7–10 days of ovarian menstrual cycle. An important criterion of treatment effectiveness was the positive dynamics in the implementation of reproductive function.

Results: during a year the number of achieved pregnancies among women of the Epigalin® group was significantly higher than the other group number.

Conclusion: the comprehensive therapy with Epigalin® of chronic endometritis in women with infertility allowes tosignificantly reduce the severity of clinical symptoms, increase reproductive function, normalize morphological function and proliferation and apoptosis processes in the endometrium.

Author Biographies

І. Т. Кишакевич, Ivano-Frankivsk National Medical University

MD, professor, Obstetrics and Gynecology Department

Н. В. Коцабин, Ivano-Frankivsk National Medical University

Assistant at the Obstetrics and Gynecology Department

В. В. Радченко, Dnipro Medical Academy of the MOH of Ukraine

Assistant of the Obstetrics, Gynecology and Perinatology Department


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How to Cite

Кишакевич, І. Т., Коцабин, Н. В., & Радченко, В. В. (2017). Endometrium in focus of the gynecologist’s attention: the role of hysteroscopy and immunohistochemistry in the diagnosis of chronic endometritis, the choice of treatment. REPRODUCTIVE ENDOCRINOLOGY, (34), 24–27. https://doi.org/10.18370/2309-4117.2017.34.24-27