Serum micro- and macroelements levels in women with polycystic ovary syndrome associated with pelvic inflammatory disease

Authors

DOI:

https://doi.org/10.18370/2309-4117.2016.27.26-29

Keywords:

polycystic ovary syndrome, inflammatory diseases of pelvic organs, manganese, nickel, zinc

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrinopathies in women of reproductive age.

The aim of the study was to determine the concentrations of some essential macro- and microelements in the body of women with PCOS. Taking into account the frequent combination of PCOS with inflammatory processes of genitals, it was decided to examine trace elements concentration in this category of women.

Study includes 3 groups of women: 30 women with PCOS against the background of inflammatory diseases of pelvic organs (I group), 22 patients with PCOS without inflammatory processes of pelvic organs (II group) and 25 healthy women (III group). In all groups it was studies macro- and microelements concentration in blood: magnesium (Mg), copper (Cu), manganese (Mn), nickel (Ni), zinc (Zn), chromium (Cr), selenium (Se), vanadium (V).

The study revealed increase zinc and nickel level, decrease manganese level in women with PCOS, that give grounds suppose their participation in the infringement of folliculogenesis and ovulation due to their properties to intensification of the lipids peroxide oxidation and reduction activity of antioxidant system, injuries cell membranes and mitochondria, gap DNA molecules and to disturb transcription processes. More high zinc and nickel concentrations in patients with PCOS in the background of inflammatory process indicates on possible inflammation role in disorders development, because proinflammatory cytokines (IL-1, IL-6, IL-18, TNF-α) leads to the zinc accumulation and elevated nickel concentrations can induce inflammation and inhibit the functional activity of macrophages and natural killer cells, setting the conditions for chronic inflammation.

Level study of trace elements (zinc, nickel and manganese) may be recommended for women with PCOS and with inflammatory diseases of pelvic organs and control their administration in complex multivitamin preparations.

Author Biographies

T. F. Tatarchuk, Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine

MD, professor, corresponding member. NAMS of Ukraine, Deputy Director for Research, Head of Endocrine Gynecology

N. V. Kosei, SI “Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”

MD, chief researcher at the Endocrine Gynecology Department

H. V. Vetokh, Advisory and Diagnostic Centre of the Dniprovskyi district of Kyiv

Obstetrician-gynecologist, Antenatal clinic № 3

S. V. Gunkov, State Enterprise “Scientific Centre of Preventive Toxicology, Nutritional and Chemical Safety named after L.I. Medved“

PhD, leading researcher

References

  1. State of the Science of Endocrine Disrupting Chemicals – 2012. United Nations Environmental Programme and the World Health Organisation, 2013.
  2. Legro, R.S., Arslanian, S.A., Ehrmann, D.A., et al. “Endocrine Society. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline.” J Clin Endocrinol Metab 98.12 (2013): 4565–92.
  3. World Health Organization. Trace Elements in Human Nutrition and Health. World Health Organization. Geneva (1996).
  4. The Rotterdam ESHRE/ASRM – sponsored PCOS consensus workshop group. “Revised 2003 consensus on diagnostic criteria and longterm healthrisks related to polycystic ovary syndrome (PCOS).” Hum Reprod 19 (2004): 41–47.
  5. Chakraborty, P., Ghosh, S., Goswami, S.K., et al. “Altered trace mineral milieu might play an aetiological role in the pathogenesis of polycystic ovary syndrome.” Biol Trace Elem Res 152.1 (2013): 9–15.
  6. Kurdoglu, Z., Kurdoglu, M., Demir, H., et al. “Serum trace elements and heavy metals in polycystic ovary syndrome.” Hum Exp Toxicol 31.5 (2012): 452–6.
  7. Zheng, G., Wang, L., Guo, Z., et al. “Association of Serum Heavy Metals and Trace Element Concentrations with Reproductive Hormone Levels and Polycystic Ovary Syndrome in a Chinese Population.” Biol Trace Elem Res 167.1 (2015): 1–10.
  8. Guler, I., Himmetoglu, O., Turp, A., et al. “Zinc and homocysteine levels in polycystic ovarian syndrome patients with insulin resistance.” Biol Trace Elem Res 158.3 (2014): 297–304.
  9. Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Chromium. U.S. Department of Health & Human Services. Public Health Service. Agency for Toxic Substances and Disease Registry. Atlanta, Georgia (2012): 592 р.
  10. Coskun, A., Arikan, T., Kilinc, M., et al. “Plasma selenium levels in Turkish women with polycystic ovary syndrome.” Eur J Obstet Gynecol Reprod Biol 168.2 (2013): 183–6.
  11. Zagrodzki, P., Krzyczkowska-Sendrakowska, M., Nicol, F. Selenium status parameters in patients with polycystic ovary syndrome Conference: 10th International Symposium on Selenium in biology and Medicine 2013. Berlin, Germany (2013): 41–2.
  12. Pykhteeva, E.G. “Metallothionein: biological functions. Metallothionein role in metal transport in the body.” Actual Problems of Transport Medicine: environment; occupational health; pathology 4 (2009): 44–58.
  13. Cheknev, S.B., Apresova, M.A., Efremova, I.E., Babayants, A.A. “IL-18 synthesis in the presence of γ-globulin metal complexes.” Medical Immunology 15.1 (2013).
  14. Avtsyn, A.P., Zhavoronkov, A.A., Rish, M.A., Strochkova, L.S. Human microelementoses. Moscow. Medicine (1991): 496 p.

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Published

2016-04-05

How to Cite

Tatarchuk, T. F., Kosei, N. V., Vetokh, H. V., & Gunkov, S. V. (2016). Serum micro- and macroelements levels in women with polycystic ovary syndrome associated with pelvic inflammatory disease. REPRODUCTIVE ENDOCRINOLOGY, (27), 26–29. https://doi.org/10.18370/2309-4117.2016.27.26-29

Issue

Section

Gynecology