Autumn nocturne


  • О. П. Танько Kharkiv city clinical maternity hospital № 7, Ukraine
  • М. В. Самойлова National Medical University named after О.О. Bohomolets, Ukraine
  • С. В. Коровай Kharkiv Medical Academy of Postgraduate Education, Ukraine
  • О. Л. Черняк Kharkiv Medical Academy of Postgraduate Education, Ukraine
  • І. С. Остапова Kharkiv City Clinical Hospital № 7, Ukraine



atrophic vulvovaginitis, vaginal index, depantol, revitaksa, methyluracilum


Atrophic vulvovaginitis is one of the most common pathological conditions at postmenopausal period. Vaginal mucosa atrophy observed in almost half of women 7–10 years after the cessation of menstruation and further their frequency reaches to 70–75%. Activation of atrophic of immune cells is characteristic for vulvovaginitis apoptosis which creates conditions for the development of secondary immunodeficiency.

The leading cause of vulvovaginal atrophic is aging lower estrogen levels resulting from ovarian failure. In addition, great importance in the development of pathological process belong to colonization resistance of vaginal mucosa.

Comparative analysis of depantol therapy, drugs and revitaksa and methyluracilum in suppositories was done to determine the clinical efficacy of depantol in atrophic vaginitis treatment. Depantol is a combined reparative, anti-inflammatory and antimicrobial drug containing chlorhexidine digluconate and panthenol.

The study included 79 women of menopausal age with a diagnosis of atrophic vaginitis. 27 of them were treated by depantol, 27 – use revitaksa, 25 – methyluracilum.

At the beginning of therapy, after completion and 2, 4 and 6 months after treatment was evaluated the vaginal index (elasticity, the volume of fluid in the vagina, pH, vaginal epithelium integrity and its moisture). To evaluate the immunostimulatory and regenerative properties of used medicines we determining the extent and nature of apoptotic processes in the immune cells of the peripheral blood of patients with atrophic vaginitis.

Use depantol helped restore vaginal index, normalization of vaginal microbial status and created conditions to eliminate the immunodeficiency. Revitaksa and methyluracilum unsignificantly improved vaginal index but did not cause significant reduction of apoptotic processes at vaginal atrophy.

According to the authors, the results of the study are important for women with menopausal atrophic vaginitises age and patients with the postcastration syndrome that on various reasons have contraindications or do not want to use estrogen therapy.

Author Biographies

О. П. Танько, Kharkiv city clinical maternity hospital № 7

MD, professor, deputy chief physician for medical part

М. В. Самойлова, National Medical University named after О.О. Bohomolets

PhD, assistant of the Obstetrics and Gynaecology Department № 2 

С. В. Коровай, Kharkiv Medical Academy of Postgraduate Education

PhD, assistant professor of Obstetrics, Gynecology and Perinatology Department

О. Л. Черняк, Kharkiv Medical Academy of Postgraduate Education

PhD, assistant professor of Obstetrics, Gynecology and Perinatology Department

І. С. Остапова, Kharkiv City Clinical Hospital № 7

Head of Gynaecology Department 


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How to Cite

Танько, О. П., Самойлова, М. В., Коровай, С. В., Черняк, О. Л., & Остапова, І. С. (2015). Autumn nocturne. REPRODUCTIVE ENDOCRINOLOGY, (25), 93–98.



Management of menopause