DOI: https://doi.org/10.18370/2309-4117.2015.24.78-82

Complex drug therapy of hemorrhagic complications in obstetric practice

О. В. Голяновський, В. В. Мехедко, А. М. Рубінштейн, М. А. Бачинська

Abstract


The article presents current data on the principles of massive blood loss pharmacotherapy, peculiarities of pharmacokinetics and pharmacodynamics of commonly used plasma expanders, the advantages of posthemorrhagic anemia prophylaxis and treatment by the injectable preparations of trivalent ferric saccharate. A clinical case of the successful complex therapy of massive blood loss in the intra- and postoperative period after cesarean section and subtotal hysterectomy without appendages has been described.


Keywords


obstetric hemorrhage; posthemorrhagic anemia; modern plasma expanders; injectable preparations of trivalent ferric saccharate

References


Beliaev, A.V. “The choice of drug for hypovolemia correction: crystalloid, colloid and colloid-colloid dilemma.” Treatment Art, 7(13) (2004): 53–58.

Glumcher, F.S., Kreydich, S.A. “The impact of colloids on hemostasis: more questions than answers.” Medical Emergency Conditions, 5(12) (2007): 104–107.

Zhezher, A.O, Mekhedko, V.V. “Blood loss in obstetrics, hemorrhagic shock: an obstetriciangynecologist tactics.” Reproductive Endocrinology, 1(21) (2015): 89-93.

Instructions for use of the drug Gecoton.

Instructions for use of the drug Volyutenz.

Instructions for use of the drug Sufer.

Tkachenko, R.A. “Intensive therapy of massive hemorrhage in obstetrics.” Medical Aspects of Women's Health, 1(2010): 28.

Conrady, G.P. Mechanisms of pathological reactions. Ed. by V. Galkin. Leningrad. Medicine (1944).

Makovetska, M. “Iron preparations for intravenous administration: new for Ukraine and settled abroad.” Health of Ukraine, 1–2 (326–327) (2014): 22–23.

Sukhikh, G.T., Serov, V.N., Savelyev, G.M., et al. Prevention and treatment of massive blood loss in obstetrics. Moscow (2010): 19 p.

Tarabrin, O.A., Nikolaev, D.C., Basenko, I.L., et al. Intensive care of obstetric hemorrhage. Odesa (2010): 40 р.

Chepkiy, L.P. “The balance of infusion therapy. Volyutenz use for fluid resuscitation of perioperative blood loss.” Emergency Conditions Medicine, 1(64) (2015): 43–48.

A uler, J.O.C., Periera, M.H.C., Gomide-Amaral, R.V., et al. “Hemodynamic effects of hypertonic sodium chloride during surgical treatment of aortic aneurysms.” Surgery, 101(1987): 594–601.

Laxenaire, M.C., Charpentier, C., Feldman, L. “Anaphylactoid reactions to colloid plasma substitutes: incidence, risk factors, mechanisms: a French multicenter prospective study.” Ann Fr Anesth Reanim, 13(1994): 301–310.

M aningas, P.A. “Hypertonic sodium chloride solutions for the prehospital management of traumatic hemorrhagic shock: A possible improvement in the standard of care.” Ann Emerg Med, 1(1986): 1411–1414.

PRAC recommendations, 2013. [http://www.ema.europa.eu/docs/en_GB/document_library/ Referrals_document/Solutions_for_infusion_containing_ hydroxyethyl_starch/European_Commission_final_decision/ WC 500162361.pdf] Last accessed August 28, 2015.

R ing, J., Messmer, K. “Incidence and severity of anaphylactoid reactions to colloid volume substitute.” Lancet, 1(1977): 467–469.

T reib, J., Baron, J.F., Grauer, M.T., Strauss, R.G. “An international view of hydroxyethyl starches.” Intensive Care Med, 25(1999): 258–268.

Van der Linden, P., Schmartz, D. Pharmacology of gelatins. In: Baron J.F., ed. Plasma volume expansion. Paris. Arnette (1992): 67–74.


GOST Style Citations


1. Беляев, А.В. Выбор препарата для коррекции гиповолемии: кристаллоидно-коллоидная и коллоидно-коллоидная дилемма / А.В. Беляев // Мистецтво лiкування. — 2004. — № 7 (13). — С. 53–58.

2. Глумчер, Ф.С. Влияние коллоидов на гемостаз: больше вопросов, чем ответов / Ф.С. Глумчер, С.А. Крейдич // Медицина неотложных состояний. — 2007. — № 5 (12). — С. 104–107.

3. Жежер, А.О. Крововтрата в акушерстві, геморагічний шок: тактика акушера-гінеколога / А.О. Жежер, В.В. Мехедко // Репродуктивна ендокринологія. — 2015. — №1 (21). — С. 89–93.

4. Инструкция по применению препарата Гекотон.

5. Инструкция по применению препарата Волютенз.

6. Инструкция по применению препарата Суфер.

7. Ткаченко, Р.А. Интенсивная терапия массивной кровопотери в акушерстве / Р.А. Ткаченко // Медицинские аспекты здоровья женщины. — 2010. — № 1. — С. 28.

8. Конради, Г.П. Механизмы патологических реакций / Под ред. В. Галкина. — Л.: Медицина. — 1944.

9. Маковецкая, М. Препараты железа для внутривенного введения: новое для Украины и устоявшееся за рубежом / М. Маковецкая // Здоров’я України. — 2014. — № 1–2 (326–327). — С.22–23.

10. Сухих, Г.Т., Серов, В.Н., Савельева, Г.М. и др. Профилактика и терапия массивной кровопотери в акушерстве. — М.: 2010. — 19 c.

11. Тарабрин, О.А., Николаев, О.К., Басенко, И.Л. и др. Интенсивная терапия акушерских кровотечений. — Одесса, 2010. — 40 c.

12. Чепкий, Л.П. Сбалансированная инфузионная терапия. Применение Волютенза с целью жидкостной ресусцитации периоперационной кровопотери / Л.П. Чепкий / Медицина неотложных состояний. — 2015. — № 1 (64). — С. 43–48.

13. A uler, J.O.C., Periera, M.H.C., Gomide-Amaral, R.V., et al. “Hemodynamic effects of hypertonic sodium chloride during surgical treatment of aortic aneurysms.” Surgery, 101(1987): 594–601.

14. Laxenaire, M.C., Charpentier, C., Feldman, L. “Anaphylactoid reactions to colloid plasma substitutes: incidence, risk factors, mechanisms: a French multicenter prospective study.” Ann Fr Anesth Reanim, 13(1994): 301–310.

15. M aningas, P.A. “Hypertonic sodium chloride solutions for the prehospital management of traumatic hemorrhagic shock: A possible improvement in the standard of care.” Ann Emerg Med, 1(1986): 1411–1414.

16. PRAC recommendations, 2013. [http://www.ema.europa.eu/docs/en_GB/document_library/ Referrals_document/Solutions_for_infusion_containing_ hydroxyethyl_starch/European_Commission_final_decision/ WC 500162361.pdf] Last accessed August 28, 2015.

17. R ing, J., Messmer, K. “Incidence and severity of anaphylactoid reactions to colloid volume substitute.” Lancet, 1(1977): 467–469.

18. T reib, J., Baron, J.F., Grauer, M.T., Strauss, R.G. “An international view of hydroxyethyl starches.” Intensive Care Med, 25(1999): 258–268.

19. Van der Linden, P., Schmartz, D. Pharmacology of gelatins. In: Baron J.F., ed. Plasma volume expansion. Paris. Arnette (1992): 67–74.





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ISSN 2411-1295 (Online), ISSN 2309-4117 (Print)