Sex steroid receptors expression in ectopic endometrium in women with different forms of endometriosis

Н. Ф. Захаренко

Abstract


Expression of antigens to estradiol and progesterone in the heterotopic endometrium was studied in order to determine the degree of hormone dependent of endometriosi various localization. Histological examination of extirpation uterus was conducted in 35 women of first groups with internal endometriosis, the second group consisted of 52 patients with external endometriosis and the third group consisted of 19 patients whom extragenital endometriosis, which was performed resection of endometriosis lesions. The obtained results showed significant reduction in the prevalence of estradiol and progesterone receptors expression in women of the first and the second groups unlike the third group. The degree of intensity of estradiol and progesterone receptors expression significantly decreased with distance of endometriosis lesions from uterus.


Keywords


ectopic endometrium; endometriosis; receptors expression; progesterone receptors; estradiol receptors

References


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GOST Style Citations


1. Вовк, І.Б. Стан активації лімфоцитів крові та сироваткові рівні медіаторів запалення за різних форм ендометріозу / І.Б. Вовк, Н.Ф. Захаренко, Т.В. Радиш // Педіатрія, акушерство і гінекологія. — 2013. — Т. 76, № 1. — С. 77–81.

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5. Strowitzki, T., Marr, J., Gerlinger, C., Faustmann, T., Seitz, C. “Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, open-label trial.” Hum Reprod, 25(2010): 633–641.

6. Stilley, J.A., Birt, J.A., Sharpe-Timms, K.L. “Cellular and molecular basis for endometriosis-associated infertility.” Cell Tissue Res, 3(349) (2012): 849–862.





DOI: http://dx.doi.org/10.18370/2309-4117.2015.21.47-49

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ISSN 2411-1295 (Online), ISSN 2309-4117 (Print)