Sex steroid receptors expression in ectopic endometrium in women with different forms of endometriosis
Keywords:ectopic endometrium, endometriosis, receptors expression, progesterone receptors, estradiol receptors
Expression of antigens to estradiol and progesterone in the heterotopic endometrium was studied in order to determine the degree of hormone dependent of endometriosi various localization. Histological examination of extirpation uterus was conducted in 35 women of first groups with internal endometriosis, the second group consisted of 52 patients with external endometriosis and the third group consisted of 19 patients whom extragenital endometriosis, which was performed resection of endometriosis lesions. The obtained results showed significant reduction in the prevalence of estradiol and progesterone receptors expression in women of the first and the second groups unlike the third group. The degree of intensity of estradiol and progesterone receptors expression significantly decreased with distance of endometriosis lesions from uterus.
- Vovk, I.B., Zakharenko, N.F., Radysh, T.V. “Activation status of blood lymphocytes and serum levels of inflammatory mediators in various forms of endometriosis.” Pediatrics, Obstetrics and Gynecology, 1(76) (2013): 77–81.
- Zakharenko, N.F., Zadorozhnia, T.D., Kalugina, L.V. “Indole-3-carbinol in the treatment of adenomyosis.” Ukrainian medicament plus, 2(15) (2013): 22–24.
- Kosei, N.V., Zakharenko, N.F., Kovbasii, V.P. “Features of local hormonal homeostasis in women of childbearing age with uterus hyperproliferative diseases.” Women Health, 1(2013): 145–149.
- A damson, D.G., Kennedy S., Hummelshoj, L. “Creating solutions in endometriosis:global collaboration through the World Endometriosis Research Foundation.” J Endometriosis, 2(2010): 3–6.
- Strowitzki, T., Marr, J., Gerlinger, C., Faustmann, T., Seitz, C. “Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, open-label trial.” Hum Reprod, 25(2010): 633–641.
- Stilley, J.A., Birt, J.A., Sharpe-Timms, K.L. “Cellular and molecular basis for endometriosis-associated infertility.” Cell Tissue Res, 3(349) (2012): 849–862.
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