Prospective study of brain natriuretic peptide in pregnant women with heart failure and congenital heart defects

Ю. В. Давыдова, Л. Г. Воронков, І. В. Чібісова, А. Ю. Лиманська, О. М. Мокрик, А. О. Огородник

Abstract


The fi rst study in Ukraine on the analysis of the level of brain natriuretic peptide (BNP) in pregnancy in women with congenital heart defects was performed. The results of this study showed that the level of BNP is a valuable diagnostic and prognostic marker of heart failure and a predictor of pregnancy complications in women with congenital heart defects. Due the value of BNP growth in pregnancy it can predict the tactics of pregnancy, timing and nature of the delivery, to develop individual therapy indications for maintenance of pregnancy.


Keywords


pregnancy; heart failure; congenital heart defects; brain natriuretic peptide

References


Chang AY, Abdullah SM, Jain T, Stanek HG, Das SR, McGuire DK, Auchus RJ, de Lemos JA Associations among androgens, estrogens, and natriuretic peptides in young women: observations from the Dallas Heart Study. J Am Coll Cardiol. 2007 Jan 2; 49 (1): 109–16.

Clerico A, Zucchelli CG, Pilo A, Passino C, Emdin M Clinical relevance of biological variation: the lesson of brain natriuretic peptide (BNP) and NT-pro BNP assay. Clin Chem Lab Med. 2006; 44(4): 366–78.

Kale A, Kale E, Yalinkaya A, Akdeniz N, Canoruc N The comparison of amino-terminal probrain natriuretic peptide levels in preeclampsia and normotensive pregnancy. J Perinat Med. 2005; 33(2):121–4.

Kaleschke G, Baumgartner H Pregnancy in congenital and valvular heart disease. // Heart 2011, November; 97 (21): 1803–9.

Lev-Sagie A, Bar-Oz B, Salpeter L, Hochner-Celnikier D, Arad I, Nir A Plasma Concentrations of N-Terminal Pro-B-Type Natriuretic Peptide in Pregnant Women near Labor and during Early Puerperium. Clin Chem. 2005 Oct; 51 (10): 1909–10.

Marelli AJ, Mackie AS, Ionescu-Ittu R, Rahme E, Pilote L Congenital heart disease in the general population: changing prevalence and age distribution // Circulation 2007 January 16; 115 (2): 163–72.

Pieper PG Prepregnancy risk assessment and counselling of the cardiac patient // Neth Heart J 2011, November; 19 (11): 477–81.

Regitz-Zagrosek V, Blomstrom LC, Borghi C et al. ESC Guidelines on the management of cardiovascular diseases during pregnancy: the Task Force on the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology (ESC). Eur Heart J 2011, December; 32 (24): 3147–97.

Tanous D, Siu S, Mason J, Greutmann M, Wald R, Parker J, Sermer M, Colman J Silversides C B-Type Natriuretic Peptide in Pregnant Women With Heart Disease // This work was supported by operating grants from the Heart and Stroke Foundation of Canada (NA 5927, NA 5662) and Canadian Institutes of Health Research (53030, 93722). The University of Toronto Pregnancy and Heart Disease Research Program acknowledges a generous donation from Mrs. Josephine Rogers. Dr. Siu is supported by the Ramsay Gunton Professorship in Cardiology of the Schulich School of Medicine and Dentistry. All other authors report that they have no relationships to disclose.Reprint requests and correspondence: Dr. Candice K. Silversides, Toronto General Hospital, 585 University Avenue, 5N-521, Toronto, Ontario M5G 2N2, Canada.

American College of Cardiology Foundation.

J Am Coll Cardiol. 2010; 56 (15): 1247–1253.

Thorne S, MacGregor A, Nelson-Piercy C Risks of contraception and pregnancy in heart disease.Heart 2006 October; 92 (10): 1520–5.

Van der Linde D, Konings EE, Slager MA et al. Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis // J Am Coll Cardiol 2011 November 15; 58 (21): 2241–7.

Yap SC, Drenthen W, Meijboom FJ et al. Comparison of pregnancy outcomes in women with repaired versus unrepaired atrial septal defect // BJOG 2009 November; 116 (12): 1593–601.

Yap SC, Drenthen W, Pieper PG et al. Pregnancy outcome in women with repaired versus unrepaired isolated ventricular septal defect // BJOG 2010 May; 117 (6): 683–9.


GOST Style Citations


Chang AY, Abdullah SM, Jain T, Stanek HG, Das SR, McGuire DK, Auchus RJ, de Lemos JA Associations among androgens, estrogens, and natriuretic peptides in young women: observations from the Dallas Heart Study. J Am Coll Cardiol. 2007 Jan 2; 49 (1): 109–16.

Clerico A, Zucchelli CG, Pilo A, Passino C, Emdin M Clinical relevance of biological variation: the lesson of brain natriuretic peptide (BNP) and NT-pro BNP assay. Clin Chem Lab Med. 2006; 44(4): 366–78.

Kale A, Kale E, Yalinkaya A, Akdeniz N, Canoruc N The comparison of amino-terminal probrain natriuretic peptide levels in preeclampsia and normotensive pregnancy. J Perinat Med. 2005; 33(2):121–4.

Kaleschke G, Baumgartner H Pregnancy in congenital and valvular heart disease. // Heart 2011, November; 97 (21): 1803–9.

Lev-Sagie A, Bar-Oz B, Salpeter L, Hochner-Celnikier D, Arad I, Nir A Plasma Concentrations of N-Terminal Pro-B-Type Natriuretic Peptide in Pregnant Women near Labor and during Early Puerperium. Clin Chem. 2005 Oct; 51 (10): 1909–10.

Marelli AJ, Mackie AS, Ionescu-Ittu R, Rahme E, Pilote L Congenital heart disease in the general population: changing prevalence and age distribution // Circulation 2007 January 16; 115 (2): 163–72.

Pieper PG Prepregnancy risk assessment and counselling of the cardiac patient // Neth Heart J 2011, November; 19 (11): 477–81.

Regitz-Zagrosek V, Blomstrom LC, Borghi C et al. ESC Guidelines on the management of cardiovascular diseases during pregnancy: the Task Force on the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology (ESC). Eur Heart J 2011, December; 32 (24): 3147–97.

Tanous D, Siu S, Mason J, Greutmann M, Wald R, Parker J, Sermer M, Colman J Silversides C B-Type Natriuretic Peptide in Pregnant Women With Heart Disease // This work was supported by operating grants from the Heart and Stroke Foundation of Canada (NA 5927, NA 5662) and Canadian Institutes of Health Research (53030, 93722). The University of Toronto Pregnancy and Heart Disease Research Program acknowledges a generous donation from Mrs. Josephine Rogers. Dr. Siu is supported by the Ramsay Gunton Professorship in Cardiology of the Schulich School of Medicine and Dentistry. All other authors report that they have no relationships to disclose.Reprint requests and correspondence: Dr. Candice K. Silversides, Toronto General Hospital, 585 University Avenue, 5N-521, Toronto, Ontario M5G 2N2, Canada.

American College of Cardiology Foundation.

J Am Coll Cardiol. 2010; 56 (15): 1247–1253.

Thorne S, MacGregor A, Nelson-Piercy C Risks of contraception and pregnancy in heart disease.Heart 2006 October; 92 (10): 1520–5.

Van der Linde D, Konings EE, Slager MA et al. Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis // J Am Coll Cardiol 2011 November 15; 58 (21): 2241–7.

Yap SC, Drenthen W, Meijboom FJ et al. Comparison of pregnancy outcomes in women with repaired versus unrepaired atrial septal defect // BJOG 2009 November; 116 (12): 1593–601.

Yap SC, Drenthen W, Pieper PG et al. Pregnancy outcome in women with repaired versus unrepaired isolated ventricular septal defect // BJOG 2010 May; 117 (6): 683–9.





DOI: https://doi.org/10.18370/2309-4117.2013.12.42-45

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

ISSN 2411-1295 (Online), ISSN 2309-4117 (Print)