Reproductive targets of endocrine disruptors

Authors

  • А. Г. Резников V.P. Komisarenko Institute of Endocrinology and Metabolism, NAMS of Ukraine, Ukraine

DOI:

https://doi.org/10.18370/2309-4117.2014.17.14-21

Keywords:

endocrine disruptors, pregnancy, fetus, reproductive function

Abstract

This review presents the novel data on negative effects of endocrine disruptors, environmental pollutants of industrial, agricultural and natural origin, that break hormonal homeostasis and hormone receptor signaling, on the female and male fetuses development and reproductive function.

Author Biography

А. Г. Резников, V.P. Komisarenko Institute of Endocrinology and Metabolism, NAMS of Ukraine

MD, professor, academician of NAMS of Ukraine, corresponding member of NAS of Ukraine, Chief of the Department of Endocrinology of Reproduction and Adaptation

References

  1. Aitken, R.J. «Falling sperm counts twenty years on: where are we now?» Asian J.
  2. Androl,15(2013):204-207.
  3. Balabanic, D. Rupnik, M. Klemencic, A.K. «Negative impact of endocrine-disrupting compounds on human reproductive health.» Reprod. Fertil. Devel,23(2011):403-416.
  4. Woodruff, T.J. «Bridging epidemiology and model organisms to increase understanding of endocrine disrupting chemicals and human health effects.» J. Steroid Biochem. Mol. Biol.,127(2011):108-117.
  5. Woodruff, T.J. Carlson, A. Schwartz, J.M. Giudice, L.C. «Proceedings of the Summit on Environmental Challenges to Reproductive Health and Fertility: Executive Summary.» Fertil. Steril,89(2008):281-300.
  6. Diamanti-Kandarakis, E. Bourguignon, J.P. Giudice, L.C. Hauser, R. Prins, G.S. Soto, A.M. Zoeller, R.T. Gore, A.C. «Endocrine-disrupting chemicals: an Endocrine Society scientific statement.» Endocr. Rev.,30(2009):293-342.
  7. Yaglova, N.V. Yaglov, V.V. «Endocrine disruptors – a new line of research in endocrinology,» Herald of RAMS,3(2012):56-61.
  8. Kalfa, N. Paris, F. Soyer-Gobillard, M.O. Daures, J.P. Sultan, C. «Prevalence of hypospadias in grandsons of women exposed to diethylstilbestrol during pregnancy: a multigenerational national cohort study.» Fertil. Steril,95(2011):2574-2577.
  9. Lu, X. Liu, Y. Kong, X. Lobie, P.E. Chen, C. Zhu, T. «Nanotoxicity: a growing need for study in the endocrine system. Small.,9(2013):1654-7171.
  10. Benotti, M.J. Trenholm, R.A. Vanderford, B.J.Holady, J.C. Stanford, B.D. Snyder, Sh.A. «Pharmaceuticals and endocrine disrupting compounds in U.S. drinking water,» Environ. Sci. Technol,43(2009):597-603.
  11. Goncharuk, E.G. Korchun, M.M. «Free radical oxidation as a universal non-specific mechanism of the damaging effect of harmful environmental factors,» J. Phys. AMS of Ukraine,1(2004):131-150.
  12. Baraboy, V.A. Reznikov, A.G. «Physiology, biochemistry and psychology of stress.» Kiev: Interservice (2013):314 p.
  13. Tsebrzhinsky, O.I. Pochernyaeva, V.F. Dimitrenko, N.A. «Prooxidant-antioxidant system of the testes and sperm.» Poltava (2008):101 p.
  14. Ballon, J.G. Reznikov, AG Tronko, M.D. Simurov, O.V. «A method of modeling of adrenocortical insufficiency.» Patent of Ukraine for useful model № 83023 (2013)Bull. Number 16.
  15. Lee, H.R. Jeung, E.B. Cho, M.H. Kim, T.H. Leung, P.C. Choi, K.C. «Molecular mechanism(s) of endocrine-disrupting chemicals and their potent oestrogenicity in diverse cells and tissues that express oestrogen receptors.» J. Cell. Mol. Med.,17(2013):1-11.
  16. Zoeller, R.T. Brown, T.R. Doan, L.L. Gore, A.C. Skakkebaek, N.E. Soto, A.M. Woodruff, T.J. Vom Saal, F.S. «Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society.» Endocrinol,153(2012):4097-4110.
  17. Germaine, M. Buck, L. «Persistent environmental pollutants and couple fecundity: an overview.» Reprod,147(2014):R97-R104.
  18. Pinto, A. Carvalho, D. «Human infertility: are endocrine disruptors to blame?» Endocr. Connect,2(2013):R15-29.
  19. Veeramachaneni, D.N.R. Klinefelter, G.R. «Phthalate-induced pathology in the foetal testis involves more than decreased testosterone production .» Reprod,147(2014):435-442.
  20. Gaspari, L. Sampaio, D.R. Paris, F. Audran, F. Orsini, M. Neto, J.B. Sultan, C. «High prevalence of micropenis in 2710 male newborns from an intensive-use pesticide area of Northeastern Brazil.» Int. J. Androl,35(2012):253-264.
  21. Cao, J. Rebuli, M.E. Rogers, J. Todd, K.L. Leyrer, S.M. Ferguson, S.A. Patisaul, H.B. «Prenatal bisphenol A exposure alters sex-specific estrogen receptor expression in the neonatal rat hypothalamus and amygdale.» Toxicol. Sci.,133(2013):157-173.
  22. Walker, D.M. Kermath, B.A. Woller, M.J. Gore, A.C. «Disruption of reproductive aging in female and male rats by gestational exposure to estrogenic endocrine disruptors.» Endocrinol.,154(2013):2129-2143.
  23. Reznikov, A.G. «Functional Teratology of neuroendocrine system: etiology, pathogenesis, prevention.» Health Protection of Ukraine,22/1(2007):19-21.
  24. Reznikov, A.G. «Hormone-neurotransmitter imprinting in the neuroendocrine control of reproduction.» New York : Harwood Academic Publishers (1994):90 р.
  25. Barker, D.J. «The developmental origins of adult disease.» J. Amer. CollegeNutr, 23(2004):588S-595S.
  26. Thiele, K. Kessler, T. Arck, P. Erhardt, A. Tiegs, G. «Acetaminophen and pregnancy: short- and long-term consequences for mother and child, J. Reprod. Immunol,97(2013):128-139.
  27. Modick, H. Weiss, T. Dierkes, G. Bruning, Th. Кoch, H.M. «Ubiquitous presence of paracetamol in human urine: sources and implications.» Reprod.,147(2014):R105-R117.
  28. Nikitin, A.I. «Phytoestrogens and reproductive function.» Reproductive medicine (Kazakhstan) 3-4(2011):12-17.
  29. Akingbemi, B. Braden, T. Kemppainen, B. «Exposure to phytoestrogens in the perinatal period affects androgen secretion by Leidig cells in the adult rat.» Endocrinol.,148(2007):4475-4478.
  30. Ruhlen, R.L. Howdeshell, K.L. Mao, J. Taylor, J.A. Bronson, F.H. Newbold, R.R. Welshons, W.V. vom Saal, F.S. «Low phytoestrogen levels in feed increase fetal serum estradiol resulting in the «fetal estrogenization syndrom» and obesity in CD-1 mice.» Environ. Health Persp,116(2008):322-328.
  31. Duškova, M. Hruškovičova, H. Šimůnkova, K. Starka L. Pařizek, A. «The effects of smoking on steroid metabolism and fetal programming.» J. Steroid. Biochem. Mol. Biol.,139(2014):138-143.
  32. Kopras, E. Potluri, V. Bermudez, M.-L. William, K. Belcher1, S. Kasper, S. «Actions of endocrine-disrupting chemicals on stem/progenitor cells during development and disease.» Endocr. Relat. Cancer,21(2014):T1-T12.
  33. Yu, W.J. Lee, B.J. Nam, S.Y. Ahn, B. Hong, J.T. Do, J.C. Kim, Y.C. Lee, Y.S. Yun, Y.W. «Reproductive disorders in pubertal and adult phase of the male rats exposed to vinclozolin during puberty.» J. Veterin. Medical Sci. // Japan Soc. Veterin. Sci,66(2004):847-853.
  34. Roeleveld, N. Bretveld, R. «The impact of pesticides on male fertility.» Curr. Opinion Obstetr. Gyn,20(2008):229-233.
  35. Swan, S.H. Elkin, E.P. Fenster, L. «The question of declining sperm density revisited: an analysis of 101 studies published 1934-1996.» Environ. Health Perspect,108(2000):961-966.
  36. Merzenich, H. Zeeb, H. Blettner, M. «Decreasing sperm quality: a global problem?» BMC Public Health,10(2010):24.
  37. Chen, M. Tang, R. Fu, G. Xu, B. Zhu, P. Qiao, S. Chen, X. Xu, B. Qin, Y. Lu, C. Hang, B. Xia, Y. Wang, X. «Association of exposure to phenols and idiopathic male infertility.» J. Hazard
  38. Mater.,250-251(2013):115-121.

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Published

2014-07-11

How to Cite

Резников, А. Г. (2014). Reproductive targets of endocrine disruptors. REPRODUCTIVE ENDOCRINOLOGY, (17), 14–21. https://doi.org/10.18370/2309-4117.2014.17.14-21

Issue

No. 17 (2014)

Section

Analytical overview

License

Copyright (c) 2014 А. Г. Резников

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