Hormonal characteristics of menstrual function of women with violations of autonomic homeostasis and mutations both of reproductive health

Authors

  • В. М. Запорожан Odessa National Medical University
  • В. В. Подолський Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine
  • З. Б. Хомінська Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine

DOI:

https://doi.org/10.18370/2309-4117.2014.17.9-13

Keywords:

vegetative homeostasis, autonomic nervous system, menstrual function, gonadotropic hormones, sex hormones

Abstract

The article presents data from a study of the relationship of autonomic nervous system disorders in women of fertile age, depending on the hormonal provision of the menstrual cycle. Hormonal homeostasis (concentration of luteinizing hormone, follicle-stimulating hormone, estrogen, progesterone, prolactin, testosterone, and cortisol) were measured in 90 women with somatoform manifestations of dysfunction of the autonomic nervous system (the main group). The control group consisted of 30 healthy women of reproductive age. The results indicate that the impact of dysfunction of the autonomic nervous system to changes in gonadotrophic regulation of menstrual function and level of sex hormones.

Author Biographies

В. М. Запорожан, Odessa National Medical University

MD, Professor, Academician of Academy of Medical Sciences of Ukraine, Rector, Head of the Obstetrics and Gynaecology Department № 1

В. В. Подолський, Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine

PhD, head of the Health Problems of Women of Childbearing Age Department

З. Б. Хомінська, Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine

MD, professor, Head of the Laboratory of Endocrinology

References

Carlson, H. «Diseases of adenohypophysis.» Endocrinology // Ed. by N. Levine.», M. Practice (1999):91-115.

Moore, R.Y. «Neuroendocrine mechanisms: Cells and Systems / Reproductive Endocrinology.» Ed. by S.S. Yena, R.B. Dzhaffe. M.: Medicine.1(1998):16-53.

Podolsky, V.V. «Functional diseases of the cardiovascular system and pregnancy.», K (2005) 247 p. // Monograph.

Podolsky, V.V. Hominska, Z.B, Gulchiy, M.M.«Features of the neuroendocrine adaptation of women of childbearing age with different levels of stress.» Proceedings of the Association of Obstetricians and Gynecologists of Ukraine. - Kyiv «Intermed» (2005):604-607.

Podolsky, V.V. Hominska, Z.B, Teterin, V.V, Gulchiy, M.M. «Role of the pineal hormone in the system antistress protect the body in women of childbearing age with psycho-emotional stress.» Journal of scientific research, 2(39)(2005):84-86.

Anggono, V. Huganir, R.L. «Regulation of AMPA receptor trafficking and synaptic plasticity.» Curr Opin Neurobiol, 22(2012):461-469.

Bagot, R.C. van Hasselt, F.N. Champagne, D.L. Meaney, M.J. Krugers, H.J. Joels M. «Maternal care determines rapid effects of stress mediators on synaptic plasticity in adult rat hippocampal dentate gyrus.» Neurobiol Learn Mem, 92(2009):292-300.

Bannerman, D.M. Bus, T. Taylor, A. Sanderson, D.J. Schwarz, I. Jensen, V. Hvalby, O. Rawlins, J.N. Seeburg, P.H. Sprengel, R. «Dissecting spatial knowledge from spatial choice by hippocampal NMDA receptor deletion.» Nat Neurosci, 15(2012):1153-1159.

Berger, S. Wolfer, D.P. Selbach, O. Alter, H. Erdmann, G. Reichardt, H.M. Chepkova, A.N. Welzl, H. Haas, H.L. Lipp, H.P. Schutz, G. «Loss of the limbic mineralocorticoid receptor impairs behavioral plasticity.» Proc Natl Acad Sci USA, 103(2006):185-200.

Brunson, K.L. Kramar, E. Lin, B. Chen, Y. Colgin, L.L. Yanagihara, T.K. Lynch, G. Baram, T.Z. (2005) «Mechanisms of late-onset cognitive decline after early-life stress.» J Neurosci, 25(2005):9328-9338.

Cahill, L. Prins, B. Weber, M. McGaugh, J.L. «Beta-adrenergic activation and memory for emotional events.» Nature, 20(1994):371.

Champagne, D.L. Bagot, R.C. van Hasselt, F. Ramakers, G. Meaney, M.J. de Kloet, E.R. Joels, M. Krugers, H. «Maternal care and hippocampal plasticity: evidence for experience dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress.» J Neurosci, 28(2008):6037-6045.

De Kloet, E.R. Oitzl, M.S. Joels, M. «Stress and cognition: are corticosteroids good or Bad guys?» Trends Neurosci, 22(1999):422-426.

De Kloet, E.R. Joels, M. Holsboer, F. «Stress and the brain: from adaptation to disease.» Nat Rev Neurosci, 6:(2005)463-475. de Quervain, D.J. Aerni, A. Schelling, G. Roozendaal, B. (2009)

Donley, M.P. Schulkin, J. Rosen, J.B. «Glucocorticoid receptor antagonism in the basolateral amygdala and ventral hippocampus interferes with long-term memory of contextual fear.» Behav Brain Res, 164(2005):197-205.

Duman, R.S. Aghajanian, G.K. «Synaptic dysfunction in depression: potential therapeutic targets.» Science, 338(2012):68-72.

Ehlers, A. Clark, D.M. Hackmann, A. McManus, F. Fennell, M. «Cognitive therapy for post-traumatic stress disorder: development and evaluation.» Behav Res Ther, 43(2005):413-431.

Gibbs, M.E. Summers, R.J. «Role of adrenoceptor subtypes in memory consolidation.» Prog Neurobiol, 67(2002):345-391.

Gourley, S.L. Kedves, A.T. Olausson, P. Taylor, J.R. «A history of corticosterone exposure regulates fear extinction and cortical NR2B, GluR2/3, and BDNF.» Neuropsychopharmacology, 34(2009):707-716.

Di, S. Malcher-Lopes, R. Halmos, K.C. Tasker, J.G. «Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism.» J Neurosci, 23(2003): 4850-4857.

Granger, A.J. Shi, Y. Lu, W. Cerpas, M. Nicoll, R.A. «LTP requires a reserve pool of glutamate receptors independent of subunit type.» Nature (2012).http://dx.doi.org/10.1038/nature11775.

Hackman, D.A. Farah, M.J. Meaney, M.J. «Socioeconomic status and the brain: mechanistic insights from human and animal research.» Nat Rev Neurosci, 11(2010):651-659.

Inoue, W. Baimoukhametova, D.V. Fuzesi, T. Cusulin, J.I. Koblinger, K. Whelan, P.J. Pittman, Q.J. Bains, J.S. «Noradrenaline is a stress-associated metaplastic signal at GABA synapses.» Nat Neurosci, 16(2013):605-612.

Joels, M. Baram, T.Z. «The neuro-symphony of stress.» Nat Rev Neurosci, 10(2009):459-466.

Joels, M. de Kloet, E.R. «Nothing is written in stone.» Biol Psychiatry, 72(2012):432-433.

Joels, M. Fernandez, G. Roozendaal, B. «Stress and emotional memory: a matter of timing.» Trends Cogn Sci, 15(2011):280-288.

Karst, H. Berger, S. Turiault, M. Tronche, F. Schutz, G. Joels, M. «Mineralocorticoid receptors are indispensable for non-genomic modulation of hippocampal glutamate transmission by corticosterone.» Proc Natl Acad Sci USA, 102(2005):19204-19207.

Karst, H. Berger, S. Erdmann, G. Schutz, G. Joels, M. «Metaplasticity of amygdalar responses to the stress hormone corticosterone.» Proc Natl Acad Sci USA, 107(2010):14449-14454.

Kopec, C.D. Real, E. Kessels, H.W. Malinow, R. «GluR1 links structural and functional plasticity at excitatory synapses.» J Neurosci, 27(2007):13706-13718.

Krugers, H.J. Alfarez, D.N. Karst, H. Parashkouhi, K. van Gemert, N. Joels, M. «Corticosterone shifts different forms of synaptic potentiation in opposite directions.» Hippocampus, 15(2005):697-703.

Krugers, H.J. Karst, H. Joels, M. «Interactions between noradrenaline and corticosteroids in the brain: from electrical activity to cognitive performance.» Front Cell Neurosci, 6(2012):15.

Li, N. Lee, B. Liu, R.J. Banasr, M. Dwyer, J.M. Iwata, M. Li, X.Y.Aghajanian, G. Duman, R.S. «mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists.» Science, 329(2010):959-964.

Li, N. Liu, R.J. Dwyer, J.M. Banasr, M. Lee, B. Son, H. Li, X.Y. Aghajanian, G. Duman, R.S. «GlutamateN-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure.» Biol Psychiatry, 69(2011):754-761.

Liu, D. Diorio, J. Tannenbaum, B. Caldji, C. Francis, D. Freedman, A. Sharma, S. Pearson, D. Plotsky, P.M. Meaney, M.J. «Maternal care, hippocampal glucocorticoid receptors, and hypothalamicpituitary-adrenal responses to stress.» Science, 277(1997):1659-16562.

Lu, W. Roche, K.W. «Posttranslational regulation of AMPA receptor trafficking and function.» Curr Opin Neurobiol, 22(2012):470-479.

Lu, J. Helton, T.D. Blanpied, T.A. Ra´cz, B. Newpher, T.M. Weinberg, R.J. Ehlers, M.D. «Postsynaptic positioning of endocytic zones and AMPA receptor cycling byphysical coupling of dynamin-3 to Homer.» Neuron, 55(2007):874-889.

Maggio, N. Segal, M. «Striking variations in corticosteroid modulation of long-term potentiation along the septotemporal axis of the hippocampus.» J Neurosci, 27(2007):5757-5765.

Newpher, T.M. Ehlers, M.D. «Glutamate receptor dynamics in dendritic microdomains.» Neuron, 58(2008):472-497.

Oitzl, M.S. DeKloet, E.R. «Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning.» Behav Neurosci, 106(1992):62-71.

Published

2014-07-11

Issue

Section

Scientific Studies