Vitamin D-deficiency states in the genesis of woman reproductive health disorders

Authors

  • Т. Ф Татарчук SI “O.M. Lukyanova Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”, Ukraine https://orcid.org/0000-0002-5498-4143
  • К. Д. Дейнюк P.L. Shupik NMAPE, Ukraine https://orcid.org/0000-0002-3021-4515
  • О. В. Занько SI “O.M. Lukyanova Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”, Ukraine https://orcid.org/0000-0002-1393-4115
  • Т. І. Юско SI “O.M. Lukyanova Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”, Ukraine
  • В. О. Тарнопольська Zhytomyr Perinatal Centre, Ukraine

DOI:

https://doi.org/10.18370/2309-4117.2018.41.84-94

Keywords:

vitamin D, vitamin D deficiency, reproductive health, cholecalciferol

Abstract

Thanks to the continuous scientific and creative search for researchers over the past almost hundred years, vitamin D preparations are finding increasing uses, from classical prevention of rickets and osteomalacia to the prevention of malignant neoplasms and mental illnesses. The article discusses the use of vitamin D in the genesis of women reproductive health disorders, as well as its impact on the condition of women in different periods - childhood, the age of menarche and adolescence, the reproductive age and the menopause.

The influence of vitamin D deficiency on a number of diseases, in particular, inflammatory diseases of the pelvic organs, breast pathology, hyperproliferative diseases is considered in detail. The results of authors’ study, which confirms the normalization of vitamin D levels in patients who received the drug containing cholecalciferol, are indicative of its effectiveness in correcting vitamin D deficiency.

As the authors of the article emphasize, encouraging patients to use preparations containing vitamin D and annual testing for D-status detection has the potential to become a modern method of preventing uterine fibroids, endometrial and breast cancer, obesity, and polycystic ovary syndrome (PCOS). Nutritional supplements and medicines containing cholecalciferol, which is the least toxic fat-soluble vitamin, with regular intake reduce the risk of progression of metabolic disorders in PCOS, promote the proper formation of pelvic bones in girls, prevent the development of postpartum depression and slow the aging and cognitive decline with age, quality of life in general.

It is advisable to test for vitamin D (25(OH)D3) serum levels in a number of population categories, in particular, for women planning pregnancy, pregnant women and women with hyperproliferative diseases. When vitamin D deficiency is detected, it is necessary to use preparations containing cholecalciferol, with dosage depending on body weight and vitamin D content in the blood serum.

Author Biographies

Т. Ф Татарчук, SI “O.M. Lukyanova Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”

MD, professor, corresponding member of the NAMS of Ukraine, deputy director for research work, head of the Endocrine Gynecology Department

К. Д. Дейнюк, P.L. Shupik NMAPE

Intern of the Obstetrics, Gynecology and Perinatology Department

О. В. Занько, SI “O.M. Lukyanova Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”

Postgraduate student at the Endocrine Gynecology Department

Т. І. Юско, SI “O.M. Lukyanova Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”

Junior researcher at the Endocrine Gynecology Department

В. О. Тарнопольська, Zhytomyr Perinatal Centre

Obstetrician gynecologist

References

  1. Holick, M.F. Evolution and function of vitamin D. Springer. Berlin. Heidelberg (2003).
  2. Povorozniuk, V.V., Balatska, N.I. “Vitamin D deficiency in Ukrainian population and risk factors for its development .” Reproductive Endocrinology 5.13 (2013): 7–13.
  3. Płudowski, P., et al. “Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe – recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency.” Endokrynologia Polska 64.4 (2013): 319–27.
  4. Idris Guessous. “Role of Vitamin D Deficiency in Extraskeletal Complications: Predictor of Health Outcome or Marker of Health Status?” BioMed Research International 2015 (2015), Article ID 563403.
  5. Lugg, S.T., Howells, P.A., Thickett, D.R. “Optimal Vitamin D Supplementation Levels for Cardiovascular Disease Protection.” Disease Markers 2015 (2015), Article ID 864370.
  6. Pludowski, P., et al. “Vitamin D supplementation guidelines.” Journal of Steroid Biochemistry & Molecular Biology 175 (2018): 125–35.
  7. Lee, J.M., Appugliese, D., Kaciroti, N., et al. “Weight status in young girls and the onset of puberty.” Pediatrics 119.3 (2007): e624–e30.
  8. Yura, S., Ogawa, Y., Sagawa, N., et al. “Accelerated puberty and late-onset hypothalamic hypogonadism in female transgenic skinny mice overexpressing leptin.” The Journal of Clinical Investigation 105.6 (2000): 749–55.
  9. Eyles, D.W., Smith, S., Kinobe, R., et al. “Distribution of the vitamin D receptor and 1α-hydroxylase in human brain.” Journal of Chemical Neuroanatomy 29.1 (2005): 21–30.
  10. Villamor, E., Marin, C., Mora-Plazas, M., Baylin, A. “Vitamin D deficiency and age at menarche: a prospective study.” The American Journal of Clinical Nutrition 94.4 (2011): 1020–5.
  11. Afsane Bahrami, Seyed Reza Mazloum, Shahrokh Maghsoudi, et al. “High Dose Vitamin D Supplementation Is Associated With a Reduction in Depression Score Among Adolescent Girls: A Nine-Week Follow-Up Study.” Journal of Dietary Supplements 15.2 (2017): 173–82.
  12. Tatarchuk, T.F., Zadorozhna, T.D., Kapshuk, I.N., et al. “Morphological features of ovarian rats with experimental D3 hypovitaminosis.” // Women’s Health 1.97 (2015): 195–8.
  13. Moore, C., Murphy, M.M., Keast, D.R., Holick, M.F. “Vitamin D intake in the United States.” Journal of the American Dietetic Association 104.6 (2004): 980–3.
  14. Kalugina, L.V., Yefimenko, O.A. “Experience of treatment of polycystic ovary syndrome.” Reproductive endocrinology 4.12 (2012): 74–8.
  15. Ganzhii, I.Y. Clinical and pathogenetic substantiation of prevention and treatment of polycystic ovary syndrome in women of different age groups. Thesis abstract for PhD degree. Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine. Kyiv (2013): 36 p.
  16. Kumar, A., et al. “Correlation of Vitamin D with Metabolic Parameters in Polycystic Ovarian Syndrome.” Journal of Family Medicine and Primary Care 6.1 (2017): 115–9.
  17. Dunlop, A.L., Taylor, R.N., et al. “Maternal Vitamin D, Folate, and Polyunsaturated Fatty Acid Status and Bacterial Vaginosis during Pregnancy.” Infectious Diseases in Obstetrics and Gynecology 2011 (2011), Article ID 216217.
  18. Hensel, K.J., et al. “Pregnancy-specific association of vitamin D deficiency and bacterial vaginosis.” American Journal of Obstetrics & Gynecology 204.1 (2011): 41.e1.
  19. Grant, W.B. “Adequate Vitamin D during Pregnancy Reduces the Risk of Premature Birth by Reducing Placental Colonization by Bacterial Vaginosis Species.” mBio 2.2 (2011).
  20. Cunha Figueiredo, Amanda C., et al. “Association between plasma concentrations of vitamin D metabolites and depressive symptoms throughout pregnancy in a prospective cohort of Brazilian women.” Journal of Psychiatric Research 95 (2017): 1–8.
  21. Mousa, A., et al. “Relationship between vitamin D and gestational diabetes in overweight or obese pregnant women may be mediated by adiponectin.” Molecular nutrition 61.11 (2017): 1700488.
  22. Ozkan, S., Jindal, S., Greenseid, K., et al. “Replete vitamin D stores predict reproductive success following in vitro fertilization.” Fertil Steril 94.4 (2009): 1314–9.
  23. Merewood, A., Mehta, S.D., Chen, T.C., et al. “Association between Vitamin D Deficiency and Primary Cesarean Section.” The Journal of Clinical Endocrinology & Metabolism 94.3 (2009): 940–5.
  24. Garland, C.F., Gorham, E.D., Mohr, S.B., Garland, F.C. “Vitamin D for cancer prevention: global perspective.” Annals of epidemiology 19.7 (2009): 468–83.
  25. O’Brien, K.M., et al. “Serum Vitamin D and Risk of Breast Cancer within Five Years.” Environmental Health Perspectives 125.7 (2017): 077004.
  26. Mousa, A., Naderpoor, N., de Courten, M.P., et al. “Vitamin D supplementation has no effect on insulin sensitivity or secretion in vitamin D-deficient, overweight or obese adults: a randomized placebo-controlled trial.” Am J Clin Nutr 105.6 (2017): 1372–81.
  27. Wang, L., et al. “Circulating Levels of 25Hydroxy-Vitamin D and Risk of Cardiovascular Disease: A Meta-Analysis of Prospective Studies.” Circulation. Cardiovascular quality and outcomes 5.6 (2012): 819–29.
  28. Faridi, K.F., et al. “Vitamin D Deficiency and Non-Lipid Biomarkers of Cardiovascular Risk.” Archives of Medical Science : AMS 13.4 (2017): 732–7.
  29. Sabry, M., Halder, S., Ait Allah, A., et al. “Serum vitamin D3 level inversely correlates with uterine fibroid volume in different ethnic groups: a cross-sectional observational study” International Journal of Women’s Health 5 (2013): 93–100.
  30. Baird, D.D., Hill, M.C., Schectman, J.M., Hollis, B.W. “Vitamin D and Risk of Uterine Fibroids.” Epidemiology (Cambridge, Mass.) 24.3 (2013): 447–53.
  31. Ciavattini, A., Delli Carpini, G., Serri, M., et al. “Hypovitaminosis D and “small burden” uterine fibroids: Opportunity for a vitamin D supplementation.” Medicine 95.52 (2016): e5698.
  32. Harris, H.R., Chavarro, J.E., Malspeis, S., et al. “Dairy-Food, Calcium, Magnesium, and Vitamin D Intake and Endometriosis: A Prospective Cohort Study.” American Journal of Epidemiology 177.5 (2013): 420–30.
  33. Manal A. Abbasa, et al. “Regression of endometrial implants treated with vitamin D3 in a rat model of endometriosis.” European Journal of Pharmacology 715.1–3 (2013): 72–5.
  34. McDonnell, S.L., Baggerly, C., French, C.B., et al. “Serum 25-Hydroxyvitamin D Concentrations ≥40 ng/ml Are Associated with >65% Lower Cancer Risk: Pooled Analysis of Randomized Trial and Prospective Cohort Study.” PLoS ONE 11.4 (2016): e0152441.
  35. Tabassi, Z., Bagheri, S., Samimi, M., et al. “Clinical and Metabolic Response to Vitamin D Supplementation in Endometrial Hyperplasia: a Randomized, Double-Blind, Placebo-Controlled Trial.” HORM CANC 8 (2017): 185.
  36. Iarotska, N.V., Zanko, E.V. “Possibilities of the use of melatonin in gynecology.” Endocrine gynecology 34.17 (2017): 96–100.
  37. Miodownik, C., Robinzon, S., Lerner, V. “Association Between Vitamin D Serum Level and Depression.” Current Psychopharmacology 5.1 (2016): 4–12.
  38. Kuma, E., Soni, M., Littlejohns, T. J., et al. “Vitamin D and Memory Decline: Two Population-Based Prospective Studies.” Journal of Alzheimer’s Disease 50.4 (2016): 1099–108.
  39. Van Schoor, N., Comijs, H., Llewellyn, D., Lips, P. “Cross-sectional and longitudinal associations between serum 25-hydroxyvitamin D and cognitive functioning.” International Psychogeriatrics 28.5 (2016): 759–68.
  40. Rinkesh Kumar Bansal, Pankaj Tyagi, Praveen Sharma. “Iatrogenic hypervitaminosis D as an unusual cause of persistent vomiting: a case report.” Journal of Medical Case Reports 8.1 (2014): 1.

Published

2018-06-15

How to Cite

Татарчук, Т. Ф., Дейнюк, К. Д., Занько, О. В., Юско, Т. І., & Тарнопольська, В. О. (2018). Vitamin D-deficiency states in the genesis of woman reproductive health disorders. REPRODUCTIVE ENDOCRINOLOGY, (41), 84–94. https://doi.org/10.18370/2309-4117.2018.41.84-94

Issue

Section

Drug therapy