Benefits of folate status correction using metafolin-contained vitamin-mineral complex

Е. В. Ших, А. А. Махова


Folic acid as substance obtained by chemical synthesis and has no own metabolic activity. Metafolin® is a synthetic compound derived from 5-methyl-tetrahydrofolate. Benefits of Metafolin include direct intake of biologically active substances; optimal form and effect of the drug even in case of homozygous and/or heterozygous genotypes 677C→T polymorphism of MTHFR. Considering high prevalence of MTHFR genetic polymorphism and its reduced activity, metafolin-contained vitamin-mineral supplements are preferred as Metafolin is the active form of folic acid which presents high bioavailability.


folic acid; MTHFR; pregnancy; Metafolin

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ISSN 2411-1295 (Online), ISSN 2309-4117 (Print)