Optimization of postoperative period after surgical interventions on the cervix





cervix, operation, antibacterial therapy, myramistin, Tamistol


The article presents the results of research on optimizing postoperative period in patients who underwent surgical interventions on cervix.

134 patients were examined who underwent radiowave conization of the cervix for histologically confirmed CIN-2. By simple randomization, they were divided into two groups: Group I (66 women) received 2.0 ceftriaxone intraoperatively, and also Tamistol® vaginally for 1 suppository once a day for 3 days before surgery and for 12 days in postoperative period; patients of Group II (68 women) underwent only intraoperative prophylactic administration of 2.0 ceftriaxone.

The laboratory studies after the operative intervention, in particular, revealed a higher microbial load in Group II than in Group I after 21 days and 1.5 months after operation. In addition, when comparing subjective and objective clinical indices, it was noted that the course of the postoperative period in Group I was easier than in Group II.

It is proved that the use of complex prophylaxis that included local application of myramistin enhanced decontamination of vagina and cervix with bacterial and viral flora, benign сourse of postoperative period, fewer complications as well as faster and more complete epithelization of cervix after intervention. Considering the high incidence of sexually transmitted diseases in population, increase of the number of multimicrobal associations and the growing resistance of microbes to antibiotics the rationality of local antiseptic therapy in the complex of purulent-septic complications prevention in case of planned surgical interventions on cervix is concluded.

Local application of the drug Tamistol® showed its high effectiveness against such pathogens as Atopobium vag. and Mobiluncus mul., considered highly specific markers of bacterial vaginosis. Given the increasing resistance of these microorganisms to nitroimidazole drugs, the proven high efficacy of myramistin against these microorganisms allows us to draw conclusions about the preferred choice of the drug Tamistol® for the prevention of purulentseptic complications during surgical interventions.

Author Biographies

Н. В. Косей, SI “Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”

MD, chief researcher at the Endocrine Gynecology Department

Т. Ф. Татарчук, SI «Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine»

MD, professor, corresponding member of the HAMS of Ukraine, deputy director for the research work, Chief of the Endocrine Gynecology Department

С. И. Регеда, SI “Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”

Senior researcher at the Endocrine Gynecology Department

Н. Н. Евтушенко, Clinic “Verum”

Highest category obstetrician-gynecologist, deputy director for surgical work 


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